IMMUNOLOGY News

Australian and US scientists reverse ageing in mice, humans could be next

Australian and US researchers have developed a compound which reverses muscle ageing in mice, saying it could be one of the keys to reversing ageing in humans. The compound gave mice more energy, toned their muscles, reduced inflammation, and led to big improvements in insulin resistance.

Study has been published in the research journal Cell: http://www.cell.com/retrieve/pii/S0092867413015213

Brain Aging is Conclusively Linked to Genes

For the first time in a large study sample, the decline in brain function in normal aging is conclusively shown to be influenced by genes, say researchers from the Texas Biomedical Research Institute in San Antonio and Yale University.

Published on PNAS: http://www.pnas.org/content/early/2013/10/30/1313735110

IL-22 inhibits intracellular growth of Mycobacterium tuberculosis

Previously, we found that IL-22 inhibits intracellular growth of Mycobacterium tuberculosis (M. tb) in human monocyte-derived macrophages (MDMs). In the current study we determined the mechanisms underlying these effects. We found W7, a phagolysosomal fusion inhibitor abrogates IL-22-dependent M. tb growth inhibition in MDMs, suggesting that IL-22 acts through enhanced phagolysosomal fusion. Our microarray analysis indicated that rIL-22 enhances the expression of an intracellular signaling molecule calgranulin A. This was confirmed by real time PCR, western blot and by confocal microscopy.

Calgranulin A siRNA abrogated rIL-22-dependent growth inhibition of M. tb in MDMs. IL-22 enhanced Rab7 expression and down regulated Rab14 expression of M. tb-infected MDMs, and these effects were reversed by calgranulin A siRNA. These results suggest that M. tb growth inhibition by IL-22 depends on calgranulin A and enhanced phagolysosomal fusion, which is associated with increased Rab7 and reduced Rab14 expression.

A copy of the article can be found online at http://jid.oxfordjournals.org/content/early/2013/09/16/infdis.jit495

Individualised medicine from the perspectives of patients using complementary therapies: a meta-ethnography approach.

Personalised (or individualised) medicine in the days of genetic research refers to molecular biologic specifications in individuals and not to a response to individual patient needs in the sense of person-centred medicine. Studies suggest that patients often wish for authentically person-centred care and personal physician-patient interactions, and that they therefore choose Complementary and Alternative medicine (CAM) as a possibility to complement standard care and ensure a patient-centred approach.

Published in BMC Complement Altern Med. 2013 Jun 3;13:124.: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679787/

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